35 research outputs found
The VIMOS VLT Deep Survey: Tracing the galaxy stellar mass assembly history over the last 8Gyr
We selected a mass-limited sample of 4048 objects from the VIMOS VLT Deep
Survey in the redshift interval 0.5<z<1.3. We used the amplitude of the 4000
Balmer break (Dn4000) to separate the galaxy population and the EW[OII]3727
line as proxy for the star formation activity. We discuss to what extent
stellar mass drives galaxy evolution, showing for the first time the interplay
between stellar ages and stellar masses over the past 8Gyr. Low-mass galaxies
have small Dn4000 and at increasing stellar mass, the galaxy distribution moves
to higher Dn4000 values as observed in the local Universe. As cosmic time goes
by, we witness an increasing abundance of massive spectroscopically ET systems
at the expense of the LT systems. This spectral transformation is a process
started at early epochs and continuing efficiently down to the local Universe.
This is confirmed by the evolution of our type-dependent stellar mass function.
The underlying stellar ages of LT galaxies apparently do not show evolution,
likely as a result of a continuous formation of new stars. All star formation
activity indicators consistently point towards a star formation history peaked
in the past for massive galaxies, with little or no residual star formation
taking place in the most recent epochs. The activity and efficiency of forming
stars are mechanisms that depend on stellar mass, and the mass assembly becomes
progressively less efficient in massive systems as time elapses. The concepts
of star formation downsizing and mass assembly downsizing describe a single
scenario that has a top-down evolutionary pattern. The role of (dry) merging
events seems to be only marginal at z<1.3, as our estimated efficiency in
stellar mass assembly can possibly account for the progressive accumulation of
passively evolving galaxies.Comment: Accepted for pubblication in A&A, 14 pages, 5 figure
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin
Alterações da motilidade esofagiana em pacientes cirróticos com varizes de esôfago não submetidos a tratamento endoscópico Esophageal motor disorders in cirrhotic patients with esophageal varices non-submitted to endoscopic treatment
RACIONAL: A cirrose hepática apresenta como uma das principais causas de morbimortalidade, a hipertensĂŁo porta com o desenvolvimento de varizes esofagianas, possibilidade de hemorragia digestiva alta e agravamento da insuficiĂŞncia hepática. É importante identificar fatores preditivos causais ou agravantes desta condição e se possĂvel, preveni-los. Nos Ăşltimos anos tem se observado a associação de distĂşrbios motores de esĂ´fago e de refluxo gastroesofágico em pacientes cirrĂłticos com varizes de esĂ´fago. OBJETIVOS: Estudar a prevalĂŞncia dos distĂşrbios de motilidade esofagiana e, entre eles, da motilidade esofagiana ineficaz, neste grupo de pacientes e seus possĂveis fatores preditivos. MÉTODOS: Avaliaram-se de maneira prospectiva, 74 pacientes com cirrose hepática e varizes esofagianas diagnosticadas por endoscopia digestiva alta, virgens de tratamento endoscĂłpico terapĂŞutico. Todos foram submetidos a um protocolo de investigação clĂnica, a esofagomanometria e 55 pacientes tambĂ©m realizaram pHmetria esofagiana ambulatorial. RESULTADOS: Alterações da motilidade esofagiana foram observadas em 44 pacientes (60%), sendo a mais prevalente a motilidade esofagiana ineficaz, verificada em 28%. Refluxo anormal foi encontrado em 35% dos pacientes. NĂŁo houve correlação entre anormalidade manomĂ©trica em geral e motilidade esofagiana ineficaz, em particular, e a presença de sintomas esofagianos ou tĂpicos de doença do refluxo, refluxo anormal, a gravidade da doença, a presença de ascite e o calibre das varizes. CONCLUSĂ•ES: A maioria dos cirrĂłticos com varizes esofagianas nĂŁo submetidos a tratamento endoscĂłpico apresenta distĂşrbios motores do esĂ´fago, sem fatores preditivos identificáveis. A importância clĂnica desses achados necessita de maior aprofundamento na questĂŁo, para elucidar seu papel definitivo.<br>BACKGROUND: The hepatic cirrhosis has as one of the main morbid-mortality causes, the portal hypertension with the development of esophageal varices, the possibility of a digestive hemorrhage and worsening of hepatic insufficiency. It is important to identify causal predictive or aggravating factors and if possible to prevent them. In the last years, it has been observed the association of esophageal motor disorders and gastro-esophageal reflux in cirrhotic patients with esophageal varices. AIMS: To study the prevalence of the esophageal motility disorders and among them, the ineffective esophageal motility, in patients with hepatic cirrhosis and esophageal varices, without previous endoscopic therapeutic and the predictives factors. METHODS: Prospectively, it has been evaluate 74 patients suffering from liver cirrhosis and esophagic varices, without previous endoscopic treatment. All of them were submitted to a clinical protocol, esophageal manometry and 55 patients also held the ambulatory esophageal pHmetry. RESULTS: Esophageal motility disorders have been found in 44 patients (60%). The most prevalent was the ineffective esophageal motility, observed in 28%. The abnormal reflux disease was diagnosed through the pHmetry in 35% of the patients. There were no correlation between the manometrical abnormality in general and the ineffective esophageal motility in particular and the esophageal or gastroesophageal reflux disease symptoms, the abnormal reflux, the disease seriousness, the ascites presence and the gauge of the varices. CONCLUSIONS: The majority of cirrhotic patients with non-treated esophageal varices present esophageal motor disorders. No predictive factor was found. The clinical relevance of these findings need more researches in the scope to define the real meaning of theses abnormalities
Novel perspectives in the management of decompensated cirrhosis
The current approaches to the management of patients with decompensated cirrhosis are based on targeted strategies aimed at preventing or treating specific complications of the disease. The improved knowledge of the pathophysiological background of advanced cirrhosis, represented by a sustained systemic inflammation strictly linked to a circulatory dysfunction, provides a novel paradigm for the management of these patients, with the ambitious target of modifying the course of the disease by preventing the onset of complications and multiorgan failure; these interventions will eventually improve patients\u2019 quality of life, prolong survival and reduce health-care costs. Besides aetiological treatments, these goals could be achieved by persistently antagonizing key pathophysiological events, such as portal hypertension, abnormal bacterial translocation from the gut, liver damage, systemic inflammation, circulatory dysfunction and altered immunological responses. Interestingly, in addition to strategies based on new therapeutic agents, these targets can be tackled by employing drugs that are already used in patients with cirrhosis for different indications or in other clinical settings, including non-absorbable oral antibiotics, non-selective \u3b2-blockers, human albumin and statins. The scope of the present Review includes reporting updated information on the treatments that promise to influence the course of advanced cirrhosis and thus act as disease-modifying agents